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KMID : 0369820040340050363
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Jorunal of Korean Pharmaceutical Sciences
2004 Volume.34 No. 5 p.363 ~ p.368
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The Effect of BSA on the Release of Cefadroxil from a Polycaprolactone Matrix
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김승렬/Kim SR
정연진/김영미/이치호/김대덕/Jung YJ/Kim YM/Lee CH/Kim DD
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Abstract
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In order to investigate the effect of bovine serum albumin (BSA), as a pore former, on the controlled release of an antibiotic from a biodegradable polymeric device, polycaprolactone (PCL)-cefadroxil matrices were prepared by the solvent casting method. The amount of cefadroxil released from various formulations at 37℃ was measured by HPLC. The duration of antimicrobial activity of matrices against S. aureus was evaluated by measuring the diameters of the inhibition zone. The morphology of the matrices was investigated by scanning electron microscopy (SEM). The release rate and extent of cefadroxil from PCL matrix increased as the loading dose and particle size of BSA/cefadroxil mixture powder increased. Cefadroxil released from the matrix exhibited antibacterial activity for up to 4 days. SEM of the cross-section of matrix showed the typical channel formation after 3 days of release study. Thus, a biodegradable polymeric matrix loaded with antibiotic/BSA mixture can effectively prevent bacterial infection on its surface, thereby bringing about an enhancement of biocompatibility of biomaterials.
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KEYWORD
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Cefadroxil, BSA, Pore former, Polycaprolactone, Controlled release
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